Show all abstracts Show selected abstracts Add to my list |
|
REVIEW ARTICLE |
|
|
|
Predicting disease severity of necrotizing enterocolitis: How to identify infants for future novel therapies  |
p. 1 |
Troy A Markel, Holly Engelstad, Brenda B Poindexter DOI:10.4103/2249-4847.128717 PMID:24741531Necrotizing enterocolitis (NEC) remains a very devastating problem within the very low birth weight neonatal population. Several experimental therapies are being tested in animal models and soon may be ready for human trials. Despite this progress, we currently have no way to identify infants who would be optimal targets for therapy. Specifically, we are unable to predict which infants will progress to the more severe Bell's stage of disease that may necessitate surgery. Ideally, an algorithm could be constructed that would encompass multiple neonatal and maternal risk factors as well as potential biologic markers of disease so that these infants could be identified in a more timely fashion. This review summarizes the known risk factors and biomarkers of disease in hopes of stimulating clinical research to identify such an "early warning" NEC algorithm. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (18) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
EBN SYNOPSIS - EVIDENCE-BASED NEONATOLOGY SYNOPSIS |
 |
|
|
|
Dextrose gel is superior to feeding alone in neonatal hypoglycemia |
p. 10 |
Rafat Mosalli DOI:10.4103/2249-4847.128718 PMID:24741532 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (2) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
High-flow nasal cannulae in very preterm infants after extubation |
p. 11 |
Lena Ignacio, Khalid AlFaleh DOI:10.4103/2249-4847.128719 PMID:24741533 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (1) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
Early enteral prophylactic iron supplementation may be preferred in preterm very low birth weight infants |
p. 14 |
Jasim Anabrees DOI:10.4103/2249-4847.128720 PMID:24741534 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (2) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
ORIGINAL ARTICLES |
 |
|
|
|
Stool calprotectin in necrotizing enterocolitis |
p. 16 |
Ehab AM Albanna, Hanan S Ahmed, Hanan Abdelaziz Awad DOI:10.4103/2249-4847.128721 PMID:24741535Background: Calprotectin is a 36 kDa protein present in the cytoplasm of the neutrophil has antimicrobial and apoptosis inducing activities. In vitro studies have shown that calprotectin inhibits the growth of various microorganisms. Necrotizing enterocolitis (NEC) remains one of the leading causes of morbidity and mortality in neonatal intensive care units (NICU), affecting up to 5% of premature infants. Fecal calprotectin is resistant to degradation and has been proposed as a useful marker of gastrointestinal inflammation. Objective: The objective of the present study is to evaluate fecal calprotectin concentrations in NEC. Study Design: Fifteen neonates with a clinical diagnosis of NEC were studied; they admitted at NICU of Zagazig University Hospital. In addition, 20 age sex matched neonates fed all caloric requirement served as the control group. All neonates were subjected to history taking, clinical examination, laboratory investigations (complete blood count, C-reactive protein) and determination of stool calprotectin. Results: There was a highly significant increase in fecal calprotectin in patients than control and there was a highly significant increase in its fecal level in died patients than living one. Also significant increase in fecal calprotectin level with increasing severity of NEC. Conclusion: Fecal calprotectin measurements could be a valuable tool for the investigation of preterm and full term infants suspected of having NEC. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (18) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
 |
Retinopathy of prematurity: Risk factors and role of antenatal betamethasone in indian preterm newborn babies |
p. 20 |
Baljeet Maini, Harish Chellani, Sugandha Arya, BP Guliani DOI:10.4103/2249-4847.128724 PMID:24741536Background: Increase in the survival of preterm neonates has led to increased incidence of retinopathy of prematurity (ROP). Among various risk factors, only prematurity is well-established and role of others is still not clear. Effect of antenatal betamethasone on ROP severity is also controversial. Available literature from India has a paucity of information. Objectives: (a) The primary aim of the following study is to find the incidence and risk factors of ROP and (b) secondary aim is to assess the effect of antenatal betamethasone on ROP. Design: prospective, observational cohort study. Setting: Tertiary level neonatal care unit. Materials and Methods: A total of 148 infants ≤ 34 weeks gestation at birth, completed the study protocol. Severe ROP was defined as stage II and higher (including plus disease) of ROP. Various perinatal factors including antenatal betamethasone were analyzed by univariate followed by multivariate analysis. Results: overall incidence of ROP (any stage) was 44.6%. Severe ROP was mainly detected in <1200 g birth weight and/or <30 weeks gestational age. Antenatal betamethasone was associated with non-severe form of ROP (P < 0.05) on univariate analysis, but could not pass multivariate logistic regression analysis. Among other perinatal factors studied, low birth weight (<1200 g) (odds ratio [OR]: 19.699, 95% confidence interval [CI]: 2.42-160.17, P = 0.005), low gestational age (<30 weeks) (OR: 36.52, 95% CI: 3.76-354.3, P = 0.002), acidosis (OR: 6.932, 95% CI: 1.16-41.33, P = 0.034) and blood transfusion (OR: 14.11, 95% CI: 1.494-133.5, P = 0.021) were associated with babies in severe ROP in an independent manner. Conclusions: Low birth weight and low gestational age emerged as independent significant risk factors along with blood transfusion and acidosis. Antenatal betamethasone may be preventive for severe ROP. More studies are however recommended. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (3) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
Perception and expectation of Iran neonatal transport expert regard to developing neonatal transport system in Iran: A qualitative research |
p. 25 |
Mohammad-Bager Hosseini, Ali Jannati, Kamal Gholipour, Mohammad Heidarzadeh, Shabnam Iezadi, Farokh Mojahed, Reza Gholi Vahidi DOI:10.4103/2249-4847.128726 PMID:24741537Introduction: This study was aimed to reach expert's expectations of neonatal transport system for developing neonatal transport system in Iran. Materials and Methods: This is a qualitative study conducted by using focus group discussion (FGD) to present expert's perspectives and expectancy about neonatal transport system. Participants was selected from all experts and specialist about neonatal transport in Iran countryside. Finally 48 experts, participate in this study. To data collection 4 FGD were conducted, data were analyzed by content analyses. All subthemes were categorized in main themes according to conceptual relationship as an expert panels opinions. In order to comply with the ethical issues involved in the study was voluntary, also permission for the recording session were taken and confidentiality was also ensured. Result: According to FGD results, 11 themes and 90 subthemes were founded related to neonatal transport system, the main identified themes included: Aims, necessity and models of neonatal transport system, organizing the transport system, management and quality of instruments in the transport system, Neonatal transport system staff, Human resource management and issue related to human resources, conditions and requirements of neonatal transport system, facilitating factors in neonatal transport system, information management and communication system and weakness of neonatal transport system. Conclusion: Neonatal transport systems in different countries must adapted according to situation and component of each country have different strength and weakness and in implementing a system must attend to geographical conditions, financial ability and access to professionals, health system structure, facilities related to neonatal health care, antenatal services in regain, health care related, health care program about neonates and pregnant women and epidemiological status and mortality and morbidity in deferent locals and regains in countryside. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (3) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
BRIEF REPORT |
 |
|
|
 |
Glucose levels in newborns with special reference to hypoglycemia: A study from rural India |
p. 35 |
Edwin Dias, Sandeep Gada DOI:10.4103/2249-4847.128729 PMID:24741538Hypoglycemia is one of the common metabolic problems in neonatal medicine. There is association between blood glucose levels and neurological development. The study involved 100 mothers and neonates blood glucose levels were measured using a standard glucometer in mother delivering babies within half an hour of delivery and in newborns at 0, 3, 6, 12, 24 h of life. Blood glucose levels were low at 0 th and 6 th h and maximum at 24 th h. Neonates born to mothers with high maternal blood glucose levels were hypoglycemic showing a negative correlation. The mean blood glucose levels were low in pre-term and post-term compared with term babies and range of blood glucose levels were wide in preterm and post term babies. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (3) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
CASE REPORTS |
 |
|
|
 |
Suppurative parotitis and submandibular sialadenitis |
p. 39 |
Raashid Hamid, Hussain A Shera, Sheikh Khurshid, Ahmad N Bhat, A Aejaz Baba, Afrozah Akhter DOI:10.4103/2249-4847.128730 PMID:24741539Suppurative involvement of salivary gland in neonates is a rare disorder. Parotid gland being the most commonly involved. We described a case of suppurative parotitis leading to abscess formation and subsequent involvement of the submandibular gland. Incision and drainage of the abscess was performed, most of the purulent material was drained. Symptoms and signs resolved within 2 days. Pus culture grew Staphylococcus aureus |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (4) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
 |
Congenital tuberculosis complicated by interstitial pulmonary emphysema |
p. 41 |
Tarsem Singh, Navreet Kaur Natt, Manu Sharma, Harmanjit Singh DOI:10.4103/2249-4847.128731 PMID:24741540We report a case of congenital tuberculosis, a rare entity itself; complicated by pulmonary interstitial emphysema, thus leading to air entrapment in lungs and prolonged oxygen dependence. The diagnosis of congenital tuberculosis is often missed and under-reported due to low index of suspicion and less sensitivity of diagnostic tools. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (2) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
 |
Poland's syndrome with absent limb anomalies |
p. 44 |
Khalid Al Faleh, Muslim Al Saadi, Shialinee Khalid-Bantuas DOI:10.4103/2249-4847.128735 PMID:24741541Poland's syndrome comprises a spectrum of chest-wall deformities affecting, to various degrees, the rib cage, the chest-wall muscles, neurovascular structures of the ipsilateral arm and the overlying breast. We present a neonate with features of depressed right chest-wall with no respiratory distress. Computed tomography showed hypolasia of the right pectoralis major muscle, with reduced subcutaneous fat on the ipsilateral side of the chest, with abnormalities of the ribs on the same side but absent upper limb deformities. There is negative history of other family members of being affected. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (7) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
 |
Cephalothoracoomphalopagus: A rare type of conjoined twin |
p. 47 |
Sunita Koreti, Nitin Prasad, G Singh Patell DOI:10.4103/2249-4847.128737 PMID:24741542We present a case of female cephalothoracoomphalopagus conjoind twin, which is extremely rare type of conjoined twins. We also review the contemprory knowledge regarding incidence, etiopathogenesis, antenatal diagnosis and outcone or the prognosis of conjoint twins. The case belong to hindu female, no history of consanguineous marriage, ingestion of drugs or exposure to any radiation. History of one abortion and one twin delivery present. Conjoind twin was cephalothoracoomphalopagus type, delivered vaginaly at 30 wks of gestion to a 25 yrs old multigravida. Management of conjoind twin still remain challenges because of multiple congenital anomalies and poor outcome is seen.
|
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
 |
Lethal progressive thoracic insufficiency in a neonate due to jarcho levin syndrome |
p. 49 |
Euden Bhutia, Arti Maria, Arushi Verma, Sidharth Kumar Sethi DOI:10.4103/2249-4847.128739 PMID:24741543A rare case of Jarcho Levin syndrome (JLS) presenting as a lethal progressive respiratory insufficiency in early neonatal period is reported. The neonate had classical features of this syndrome including vertebral segmentation defects, typical costo-vertebral fusion defects and scoliosis resulting in small thoracic volume and limited chest expansion; all consistent with a clinical diagnosis of JLS with thoracic insufficiency. In addition, our case had a rare association of dextrocardia and acyanotic congenital heart disease. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (3) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
IMAGES IN CLINICAL NEONATOLOGY |
 |
|
|
 |
A rare association of pyloric stenosis and situs inversus: Impact on diagnosis and treatment |
p. 51 |
Anil Kumar Gupta, Lokesh Yadav, Manish Pathak DOI:10.4103/2249-4847.128742 PMID:24741544A rare case of 23 days old boy is reported having congenital hypertrophic pyloric stenosis with situs inversus. Incidentally detected secondary diagnosis obscured the primary diagnosis by altering the physical examination findings. Diagnosis was made by ultrasonography (USG) which revealed congenital hypertrophic pyloric stenosis with situs inversus. Clinical details, diagnosis and management are discussed. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
 |
An unusual association of microcephalic osteodysplastic primordial dwarfism type I with cardiac and brain anomalies |
p. 53 |
Euden Bhutia, Arushi Verma, Amit Kumar Gupta, Arti Maria DOI:10.4103/2249-4847.128743 PMID:24741545Less than 100 cases of primordial dwarfism have been reported worldwide out of which Microcephalic osteodysplastic primordial dwarfism type I comprise about <30 cases. We report a rare case of extreme growth failure in a neonate with primordial dwarfism of antenatal onset due to Microcephalic osteodysplastic primordial dwarfism type I. Our case is also unique in being associated with hitertho unreported association of subpulmonic ventricular septal defect and a dorsal interhemispheric cyst in the brain. |
[ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
|
LETTERS TO EDITOR |
 |
|
|
 |
Maple syrup urine disease and oculocutaneous albinism in twins |
p. 55 |
Divya Nagabushana, Asha Benakappa DOI:10.4103/2249-4847.128744 PMID:24741546 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|
 |
A sporadic case of klippel-feil syndrome type 2 |
p. 57 |
Deepti Sharma, Chandra Madhur Sharma DOI:10.4103/2249-4847.128748 PMID:24741547 |
[HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (1) ] [PubMed] [Sword Plugin for Repository]Beta |
|
|
|
|
|