Journal of Clinical Neonatology

CASE REPORT
Year
: 2020  |  Volume : 9  |  Issue : 2  |  Page : 146--148

Hemolytic disease of the newborn due to anti-e


Hammam A H. Ali, Osayd Samer Zohud 
 Department of Medical Laboratory Sciences, Faculty of Health Professions, Al-Quds University, Jerusalem; Department of Laboratory and Blood Bank, Yaser Arafat Hospital, Palestinian Ministry of Health, Salfit, State of Palestine

Correspondence Address:
Dr. Hammam A H. Ali
Department of Medical Laboratory Sciences, Faculty of Health Professions, Al-Quds University, Jerusalem; Department of Laboratory and Blood Bank, Yaser Arafat Hospital, Palestinian Ministry of Health, Salfit, State of Palestine

In Palestine, antibody screening is done antenatally only for pregnant women who are Rh-D negative. However, we report the first hemolytic disease of the newborn (HDN) due to anti-e in Palestine, illustrating the importance of alloantibodies other than anti-D as a cause of HDN. A pregnant woman had e-antigen negative and her blood group was B positive developed alloantibody against her infant erythrocyte e-antigen that lead to severe jaundice due to fetal erythrocyte destruction by this maternal alloantibody. Postnatal workup for the severe hyperbilirubinemia indicated that the newborn' erythrocytes were sensitized by the maternal anti-e alloantibody. Furthermore, the positive direct Coombs test was reported. This case highlights the importance of antibody screening for all pregnant women irrespective of the D antigen status to detect and manage erythrocyte alloimmunization to any other clinically significant blood group antigens.


How to cite this article:
Ali HA, Zohud OS. Hemolytic disease of the newborn due to anti-e.J Clin Neonatol 2020;9:146-148


How to cite this URL:
Ali HA, Zohud OS. Hemolytic disease of the newborn due to anti-e. J Clin Neonatol [serial online] 2020 [cited 2020 Dec 1 ];9:146-148
Available from: https://www.jcnonweb.com/article.asp?issn=2249-4847;year=2020;volume=9;issue=2;spage=146;epage=148;aulast=Ali;type=0