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CASE REPORT
Year : 2020  |  Volume : 9  |  Issue : 4  |  Page : 300-304

Recurrent seizures in a neonate with intracranial hemorrhage and congenital factor VII deficiency: A missed diagnosis


1 Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Rajesh Kashyap
Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow - 226 014, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcn.JCN_67_20

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Intracranial hemorrhage (ICH) is an uncommon life-threatening event occurring in full-term neonates. Neonates with inherited coagulation disorders are at a greater risk of developing ICH. Factor VII deficiency is associated with spontaneous and often recurrent ICH in infants. Factor VII deficiency is often confused with Vitamin K deficiency bleeding (VKDB) as the clinical and laboratory findings in both these conditions are similar. We present the case of a neonate who had recurrent seizures secondary to ICH since the 11th day of life and was initially managed as VKDB disorder. Inherited Factor VII deficiency was diagnosed only on the 44th day of life. This delay in diagnosis and appropriate treatment was associated with severe morbidity in the infant. Prompt recognition of ICH and underlying coagulation defect is the key to successful management of these patients.


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