Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 881
 
About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Advertise Login 
     
CASE REPORT
Year : 2020  |  Volume : 9  |  Issue : 4  |  Page : 286-288

Pancytopenia with atypical skin manifestation in a term newborn


Department of Neonatology, PGIMER and Dr. RML Hospital, New Delhi, India

Correspondence Address:
Prof. Arti Maria
PGIMER and Dr. RML Hospital, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcn.JCN_109_19

Rights and Permissions

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder in neonates characterized by hyperinflammation along with abnormal proliferation and accumulation of mononuclear cells within various tissues due to pathologic immune activation. Cutaneous manifestations in HLH are rare and have been reported between 6% and 65% of the cases in the literature. We describe the case of a term newborn with HLH and atypical skin manifestations. The baby was diagnosed as a case of primary HLH according to HLH-2004 guidelines based on typical clinical and laboratory findings. No specific genetic defect was identified. Subsequently, during hospital stay, the baby developed atypical skin lesions suggestive of “Noma Neonatorum.” He was managed aggressively with antibiotics as per the culture sensitivity report. However, the baby succumbed to rapidly progressive HLH. This is the first case report we are aware of “Noma Neonatorum” occurring in an infant with HLH. Although the cutaneous manifestations are not common, “Noma Neonatorum” should be kept in mind as an accompanying condition in neonates with HLH.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
  Search Pubmed for
  Search in Google Scholar for
Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed72    
    Printed0    
    Emailed0    
    PDF Downloaded14    
    Comments [Add]    

Recommend this journal