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Year : 2018  |  Volume : 7  |  Issue : 1  |  Page : 48-50

Acute hemoglobin increase after transfusion and immunoglobulin for rhesus hemolytic disease of the newborn

1 Department of Paediatrics, Leeds General Infirmary, Leeds, UK
2 Medical School, University of Nottingham, Nottingham, UK
3 Department of Radiology, Hull and East Yorkshire NHS Trust, Hull, UK
4 Department of Paediatrics, Hull and East Yorkshire NHS Trust, Hull, UK

Correspondence Address:
Dr. Hilary Klonin
Hull Royal Infirmary, Anlaby Road, Hull HU3 2JZ, FRCPCH
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcn.JCN_48_17

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We describe two infants with severe hemolytic disease of the fetus and newborn (HDFN) with hepatosplenomegaly treated with intravenous immunoglobulin. Packed red blood cells (PRBC) were transfused resulting in an acute disproportionate increase in hemoglobin with clinical consequences in one case. These cases appear to highlight previously unreported sequelae. We discuss a hypothetical mechanism and suggest that the effect warrants further research as a possible way to decrease the need for and risks of PRBC transfusion in HDFN.

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