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Year : 2017  |  Volume : 6  |  Issue : 4  |  Page : 259-261

Aminophylline-associated hyponatremia in a premature infant

Department of Pediatrics, University of Arizona, Tucson, Arizona, USA

Correspondence Address:
Ranjit I Kylat
Department of Pediatrics, Division of Neonatal-Perinatal Medicine and Developmental Biology, College of Medicine, University of Arizona, P. O. Box 245073, 1501 N Campbell Avenue, Tucson, AZ 85724
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcn.JCN_1_17

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Hyponatremia is common in preterm infants. The causes are usually related to the inability of the premature kidneys to excrete a given water load, excessive sodium losses, or inadequate sodium intake. Here, we present a case of severe hyponatremia in an extreme preterm infant, associated with the use of aminophylline. Aminophylline was administered intravenously on day 1 for the treatment of apnea of prematurity. On day 3, the patient developed hyponatremia which was not responsive to sodium replacement and fluid restriction. Due to concerns of aminophylline-induced hyponatremia, aminophylline was discontinued on day 6, and within 48 h of discontinuation, serum sodium normalized without the need for sodium supplementation. The purpose of the case report is to present a rare complication associated with aminophylline use and to shed light on potential deleterious effects associated with drug shortages.

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