Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 216
 
About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Advertise Login 
     
CASE REPORT
Year : 2016  |  Volume : 5  |  Issue : 2  |  Page : 122-124

Hyperinsulinemic hypoglycemia and thrombocytopenia in a neonate: Treatment and review of literature


Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA

Correspondence Address:
Bina Shah
Department of Pediatrics, Divisions of Pediatric Endocrinology, New York University School of Medicine, 550 First Avenue, New York, NY 10016
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2249-4847.179924

Rights and Permissions

Transient hyperinsulinism and thrombocytopenia can occur in neonates following exposure to perinatal stress and birth asphyxia. However, little is known about whether there is a direct association between neonatal hyperinsulinism and thrombocytopenia. We report a case of transient hyperinsulinism and thrombocytopenia, both of which improved after administration of diazoxide in a full-term neonate born by emergency cesarean section and required resuscitation. The newborn had severe hypoglycemia at 8 h of life and continued to have episodes of hypoglycemia while on a continuous glucose infusion rate. The glucagon stimulation test was positive confirming hyperinsulinism and the patient was started on diazoxide. Concomitantly, the neonate also had severe thrombocytopenia and required four platelet transfusions in the first 8 days. Within 24 h after starting diazoxide, both blood glucose and platelet counts improved. We speculate a possible association of hyperinsulinism with thrombocytopenia.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
  Search Pubmed for
  Search in Google Scholar for
Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7065    
    Printed93    
    Emailed0    
    PDF Downloaded499    
    Comments [Add]    

Recommend this journal