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Year : 2014  |  Volume : 3  |  Issue : 3  |  Page : 179

Stool calprotectin and necrotizing enterocolitis

Hainan Medical University, China; Faculty of Medicine, University of Nis, Serbia; Joseph Ayobabalola University, Nigeria; Surin Rajabhat University, Surin, Thailand

Date of Web Publication8-Sep-2014

Correspondence Address:
Prof. Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2249-4847.140421

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How to cite this article:
Wiwanitkit V. Stool calprotectin and necrotizing enterocolitis. J Clin Neonatol 2014;3:179

How to cite this URL:
Wiwanitkit V. Stool calprotectin and necrotizing enterocolitis. J Clin Neonatol [serial online] 2014 [cited 2021 Oct 26];3:179. Available from: https://www.jcnonweb.com/text.asp?2014/3/3/179/140421


The recent report on "stool calprotectin in necrotizing enterocolitis (NEC)" is very interesting. [1] Albanna et al. concluded that "fecal calprotectin measurements could be a valuable tool for the investigation of preterm and full-term infants suspected of having NEC. [1]" Although the present report suggests a usefulness of stool calprotectin measurement, there are many concerns on the test. First, many conditions can result in false-positive results of calprotectin measurement. The good examples are cirrhosis or users of nonsteroidal anti-inflammatory drugs. [2] Second, according to the metanalysis, the discriminative power of stool calprotectin measurement is not good in pediatric patients. [3] Finally, the cost-effectiveness of stool calprotectin measurement is still controversial. [4]

  References Top

1.Albanna EA, Ahmed HS, Awad HA. Stool calprotectin in necrotizing enterocolitis. J Clin Neonatol 2014;3:16-9.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Carroccio A, Iacono G, Cottone M, Di Prima L, Cartabellotta F, Cavataio F, et al. Diagnostic accuracy of fecal calprotectin assay in distinguishing organic causes of chronic diarrhea from irritable bowel syndrome: A prospective study in adults and children. Clin Chem 2003;49:861-7.  Back to cited text no. 2
3.van Rheenen PF, Van de Vijver E, Fidler V. Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: Diagnostic meta-analysis. BMJ 2010;341:c3369.  Back to cited text no. 3
4.Waugh N, Cummins E, Royle P, Kandala NB, Shyangdan D, Arasaradnam R, et al. Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: Systematic review and economic evaluation. Health Technol Assess 2013;17:xv-xix, 1-211.  Back to cited text no. 4


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