Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 208
 
About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Advertise Login 
     


 
 Table of Contents  
CASE REPORT
Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 93-94

Salmonella paratyphi B septicemia in a neonate


Department of Microbiology, Fr. Muller Medical College, Mangalore, Karnataka, India

Date of Web Publication13-Aug-2013

Correspondence Address:
Meena Dias
S-3, Casa Leila, S. L. Mathias Road, Falnir, Mangalore, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2249-4847.116409

Rights and Permissions
  Abstract 

Septicemia is a major cause of death in neonates especially in developing countries. We report a case of septicemia in a neonate due to Salmonella Paratyphi B. The baby responded well to therapy and recovered completely.

Keywords: Neonatal septicemia, Salmonella Paratyphi B


How to cite this article:
Bhat P, Dias M, Hegde R, Pinto H. Salmonella paratyphi B septicemia in a neonate. J Clin Neonatol 2013;2:93-4

How to cite this URL:
Bhat P, Dias M, Hegde R, Pinto H. Salmonella paratyphi B septicemia in a neonate. J Clin Neonatol [serial online] 2013 [cited 2021 May 6];2:93-4. Available from: https://www.jcnonweb.com/text.asp?2013/2/2/93/116409


  Introduction Top


Salmonellosis is a major cause of bacterial enteric illness. Young children are more prone to infection and are at increased risk of severe complications like septicemia and meningitis. [1] Even though there are case reports of neonatal septicemia due to salmonella, [2] Salmonella enterica serotype Paratyphi B causing neonatal sepsis in India is rare. [3] We report here a case of neonate with Salmonella enterica serotype Paratyphi B septicemia.


  Case Report Top


A 6-day-old baby girl presented with fever and blood in stools and vomitus since 1 day. She was a term, small for gestational age, delivered by normal vaginal delivery with a birth weight of 1.55 kg in a private hospital born to a economically poor and severely anemic mother. She was supplemented with top up feeds along with breast milk and was discharged on 3 rd day. Antenatal and perinatal history was uneventful. Her Apgar score was not available. On examination she was febrile (101°F), pulse rate 160 beats/min and respiratory rate 50 breaths/min. She appeared dehydrated. Her systemic examination was unremarkable. A diagnosis of neonatal sepsis was made and baby was started empirically on intravenous piperacillin/tazobactam 80 mg/kg body weight 8 th hourly and cefotaxime 60 mg/kg body weight 8 th hourly. The drug was chosen based on the sensitivity pattern of the prevalent bacteria usually causing sepsis in the hospital nursery.

Screening for sepsis was done. Laboratory investigations revealed increased C-reactive protein-169.8 mg/L, serum urea 227 mg/dl and serum creatinine was 3.6 mg/dl. Hemogram showed Hb 15.7 gm%, white blood cell count on admission was 24,200/cumm with 54% neutrophils and 40% lymphocytes 6% monocytes and platelet count of 92,000/mm 3 suggesting sepsis and prerenal failure. Blood collected at the time of admission flagged positive after 8 hours by BD BACTEC 9120 (Becton Dickinson). The isolate, Gram-negative bacilli is identified as Salmonella enterica serotype Paratyphi B (Agglutinating serum, Remel Europe, Ltd) which was sensitive to ampicillin, ceftriaxone, co-trimoxazole, ciprofloxacin, cefotaxim, ceftriaxone and piperacillin/tazobactam. Stool culture was negative. CSF culture was not done as there were no symptoms of meningeal irritation. Treatment was continued with same antibiotics. Baby's condition improved with 5 days of treatment and was discharged on 9 th day. Subsequently, the mother gave history of typhoid fever 3 years back. Mother's stool was cultured to rule out carrier state. Mother's stool culture yielded Salmonella enterica serotype Paratyphi B with the same antibiotic sensitivity pattern. Blood culture and Widal test were negative. Mother was advised to take treatment for carrier state and repeat stool culture after treatment. But she did not turn for follow-up.


  Discussion Top


Neonatal septicemia is a major cause of morbidity and mortality in developing countries. Survival depends on the urgent prompt diagnosis and institution of therapy.

The possible routes of acquiring neonatal Salmonellosis are by vertical transmission, feco-oral route, environmental transmission through contaminated top feeds, via breast milk and transplacental route. [2],[4],[5] In this case could be through perineal contamination during delivery or through feco-oral route as mother was a carrier.

Gastric acidity represents the initial barrier to Salmonella colonization and conditions that increase gastric pH significantly increase susceptibility to infection. Neonates and young infants have hypochlohydria and rapid gastric emptying, which contributes to their increased vulnerability to symptomatic Salmonellosis. In infants who typically take fluids, the inoculums size that can produce disease is also comparatively smaller because of faster transit through the stomach. [6]

Neonatal salmonellosis can be identified with a high index of suspicion. Salmonella species are a cause of early onset sepsis in neonates and identifying the source of infection is highly important in such cases.

 
  References Top

1.Dharsandia Milan R, Soni Sumeeta T, Vegad Mahendra M. Salmonella Paratyphi B meningitis, isolated from CSF. NJIRM 2010;1:55-6.  Back to cited text no. 1
    
2.Mohanty S, Gaind R, Sehgal R, Chellani H, Deb M. Neonatal sepsis due to Salmonella Typhi and Paratyphi A. J Infect Dev Ctries 2009;3:633-8.  Back to cited text no. 2
    
3.Malenie R. Neonatal septicaemia by Salmonella Paratyphi B. Indian J Med Microbiol 2006;24:76-7.  Back to cited text no. 3
[PUBMED]  Medknow Journal  
4.Raveendran R, Wattal C, Sharma A, Kler N, Garg P, Gujral K, et al. Vertical transmission of Salmonella Paratyphi A. Indian J Pediatr 2007;74:784-6.  Back to cited text no. 4
    
5.Cooke FJ, Ginwalla S, Hampton MD, Wain J, Ross-Russell R, Lever A, et al. Report of neonatal meningitis due to salmonella enteric serotype agona and review of breast milk-associated neonatal Salmonella Infections. J Clin Microbiol 2009;47:3045-9.  Back to cited text no. 5
    
6.Bhutto ZA. Nontyphoidal Salmonellosis Ch 190. In: Kliegman, Stanton, St Geme, Schor, Behrman, editors. Nelson Text book of Paediatrics. Vol. 1. 19 th ed. Saunders Elsevier; Philadelphia. 2012. p. 948-54.  Back to cited text no. 6
    



This article has been cited by
1 Neonatal Salmonella Paratyphi B Sepsis: A Case Report
Sumit Rai,Ruchi Rai,D. K. Singh,Sumi Nandwani
Journal of Neonatology. 2020; 34(4): 241
[Pubmed] | [DOI]
2 Vertical transmission of Salmonella enterica serotype Paratyphi A leading to abortion
Shveta Sethi,Vikas Gautam,Kirti Gupta,Vanita Suri,Archana Angrup
JMM Case Reports. 2017; 4(11)
[Pubmed] | [DOI]
3 Characterisation of Antimicrobial Resistance in Salmonellae during 20142015 from Four Centres Across India: An ICMR Antimicrobial Resistance Surveillance Network Report
Sushila Dahiya,Priyanka Sharma,Bhavana Kumari,Sangeeta Pandey,Rooma Malik,Neelam Manral,Balaji Veeraraghavan,Agila Kumari Pragasam,Pallab Ray,Vikas Gautam,Sujata Sistla,Subhash Chandra Parija,Kamini Walia,Vinod Ohri,Bimal Kumar Das,Seema Sood,Arti Kapil
Indian Journal of Medical Microbiology. 2017; 35(1): 61
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
Similar in PUBMED
  Search Pubmed for
  Search in Google Scholar for
Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Case Report
Discussion
References

 Article Access Statistics
    Viewed2169    
    Printed74    
    Emailed0    
    PDF Downloaded229    
    Comments [Add]    
    Cited by others 3    

Recommend this journal