Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 926
 
About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Advertise Login 
     
ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 3  |  Page : 151-154

Systemic Candida infection in preterm babies: Experience from a tertiary care hospital of North India


Department of Pediatrics, SKIMS, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Dr. Javeed Iqbal Bhat
Department of Pediatrics, SKIMS, Soura, Srinagar - 190 011, Jammu and Kashmir
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcn.JCN_9_19

Rights and Permissions

Background: Neonatal fungal infection is an important cause of late-onset sepsis with very high mortality. The incidence is progressively increasing due to a marked improvement in the survival of low-birth weight neonates. Materials and Methods: This was a 2-year observational study. Very low-birth weight (VLBW) and extremely low-birth weight (ELBW) with suspected fungal sepsis were enrolled. All suspected neonates were evaluated for possible Candida infection. Complete clinicodemographic and laboratory profile was noted from the study participants. The main outcome measure was hospital incidence, clinical profile, and the frequency of end-organ involvement. Results: During the study, 304 ELBW and VLBW neonates were screened for invasive fungal sepsis. Sixty-four neonates were found positive for invasive Candida sepsis making the incidence of 11.6%. Majority of patients developed worsening of respiratory distress and shock. Necrotizing enterocolitis (NEC) was seen in 10 patients and disseminated intravascular coagulation (DIC) in nine patients. Nearly 7.8% had cerebrospinal fluid culture positive for Candida. Renal abscess was seen in two patients. Endohpthalmitis and endocarditis each were observed in one patient. The mortality rate in our study group was 55%. Conclusion: We found 11.9% incidence of invasive fungal incidence. Majority of neonates developed worsening of respiratory distress, shock, NEC, DIC, and thrombocytopenia. End-organ damage was noticed in 14% of patients. Mortality was around 55% in our cohort.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
  Search Pubmed for
  Search in Google Scholar for
Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed325    
    Printed36    
    Emailed0    
    PDF Downloaded121    
    Comments [Add]    

Recommend this journal