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Year : 2019  |  Volume : 8  |  Issue : 2  |  Page : 67-70

Incidence of meningitis in neonates with late-onset sepsis at a Tertiary Care Center in Western India: An observational study

Department of Neonatology, Surya Children's Medicare Pvt. Ltd., Mumbai, Maharashtra, India

Correspondence Address:
Dr. Bhawan Deep Garg
Department of Neonatology, Surya Children's Medicare Pvt. Ltd., S. V. Road, Santacruz West, Mumbai - 400 054, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcn.JCN_64_18

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Objective: The objective of this study was to determine the incidence of meningitis in neonates with late-onset sepsis (LOS) in the West India population. Materials and Methods: This prospective observational study enrolled 208 neonates with signs and symptoms suggestive of sepsis with positive C-reactive protein at or more than 72 h of postnatal age. Results: Out of total 208 neonates with LOS, 12.5% neonates had meningitis. The incidence of LOS in preterm and low-birth-weight neonates were 73.6% and 72.1%, respectively. Most common presenting features in neonates with LOS with or without meningitis were respiratory distress (72.6%), followed by lethargy (68.8%) and refusal to feed (63%). Blood culture was positive in 53.8% neonates who had meningitis. Mortality in neonatal meningitis was 3.84%. Conclusion: This study demonstrated that a significant number of neonates with LOS have coexistent neonatal meningitis. Our study highlights the diagnostic utility of routine lumbar puncture in neonates with clinical features of sepsis.

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