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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 3  |  Page : 141-145

A retrospective cohort study patient chart review of neonatal sepsis investigating responsible microorganisms and their antimicrobial susceptibility


1 Hospital of Pediatrics, Neonatal Intensive Care Unit, Riyadh, Saudi Arabia
2 Hospital of Pediatrics, Department of Pediatric Infectious Diseases, Riyadh, Saudi Arabia
3 Department of Regional Laboratory, King Saud Medical City, Riyadh, Saudi Arabia
4 Department of Pharmacy, King Saud Medical City, Riyadh, Saudi Arabia
5 Department of Clinical Pharmacy, King Saud Medical City, Riyadh, Saudi Arabia

Correspondence Address:
Dr. Mountasser M Al-Mouqdad
Hospital of Pediatrics, Neonatal Intensive Care Unit, King Saud Medical City, Riyadh
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcn.JCN_18_18

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Background and Aims: Microorganisms responsible for neonatal sepsis have developed increased drug resistance to commonly used antibiotics making treatment extremely difficult. To select an appropriate antibacterial therapy, the common pathogens causing sepsis in neonates and their bacterial resistance should be known first. The present study was designed to investigate the microorganisms responsible for neonatal sepsis in King Saud Medical City Neonatal Intensive Care Unit (NICU). In addition, we sought to determine the antibiotic susceptibility of the isolated microorganisms for planning a strategy for the management of neonatal sepsis. Subjects and Methods: This study is a retrospective cohort study, was conducted at the NICU of King Saud Medical City. A total of 295 inborn premature infants aged ≤180 days and received antibiotics. The study lasted for 12 months. The primary outcome measures were the incidence of the bacterial infection and its etiology in cases with suspected sepsis. The secondary outcome measure was the bacterial sensitivity to antibiotics used. Results: A total of 70 different microorganisms were isolated from culture-positive samples from 57 neonates. Gram-positive organisms (57%) were more common than Gram-negatives (38.5%), coagulase-negative staphylococci were the most isolated pathogens (44%), and the prevalence of fungal sepsis was low (4.3%). The prevalence of antimicrobial resistance was low. Among Gram-positives, there were only three methicillin-resistant Staphylococcus aureus isolates, and no vancomycin-resistant enterococci. Whereas three of the Gram-negative isolates were resistant, two Enterobacter cloacae and one Pseudomonas aeruginosa, and none of Candida species were resistant. Conclusion: Antimicrobial resistance was low in our study, mostly because of the restriction of broad-spectrum antibiotics.


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