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Year : 2017  |  Volume : 6  |  Issue : 2  |  Page : 106-108

Maternal chronic hepatitis B and entecavir therapy associated with meconium peritonitis in a neonate

1 Department of Paediatrics, North West Regional Hospital, Tasmanian Health Service, Tasmania, Australia
2 Clinical School, University of Tasmania, Private Bag 68, HOBART TAS 7001, Australia

Correspondence Address:
Anutosh Shee
North West Regional Hospital, Tasmanian Health Service, Tasmania
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcn.JCN_96_16

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We present a case of meconium peritonitis in a neonate born to a mother with chronic hepatitis B virus (HBV) infection with low viral load treated with entecavir. There have been a small number of case reports describing maternal acute or fulminant HBV associated with meconium peritonitis, but this case is the first to our knowledge to represent this association in the setting of chronic infection with low viral load, suggesting an alternate mechanism does exist possibly related to the chronic inflammation. There have been no adequately controlled trials of entecavir therapy in pregnant women to date, thus its effects on the human fetus are currently unknown. This case report suggests that further investigation is required into the effects of chronic HBV and its antiviral treatment on fetal development in utero.

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