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ORIGINAL ARTICLE
Year : 2017  |  Volume : 6  |  Issue : 1  |  Page : 10-14

Melatonin administration as an adjuvant therapy in neonatal necrotizing enterocolitis


1 Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Department of Medical Biochemstry, Faculty of Medicine, Tanta University, Tanta, Egypt

Correspondence Address:
Prof. Mohamed Shawky Elfrargy
El Nahas Street, Tanta
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2249-4847.199761

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Objective: Determine the value of melatonin as an adjuvant therapy in treating necrotizing enterocolitis (NEC) in neonates. Patients and Methods: A prospective clinical trial study was conducted on 50 neonates which suffer from picture like NEC to detect cases with evident NEC diagnosed on the basis of both clinical and laboratory criteria. Enrolled neonates were divided into two groups: Studied group (G I) (n = 25) received melatonin and antibiotics, while the control group (G II) (n = 25) was treated with antibiotics only. Melatonin was administered as 20 mg for 3 consecutive days and antibiotics were administered according to a standard protocol. Results: Showed comparison between Group I and Group II according to incidence of NEC at the onset of the research and after 1 week of onset wherein Group I there were 6 neonates out of 25 neonates at the onset of research suffering from NEC and became 1 neonate only after 1 week showing significant difference in Group I (P < 0.05) while in Group II there were 4 neonates at the onset of research suffering from NEC and became 3 neonates after 1 week showing nonsignificant difference P > 0.05. Conclusion: Melatonin administration as an adjuvant therapy in neonatal NEC treatment is associated with improvement of clinical and laboratory outcome.


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