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ORIGINAL ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 3  |  Page : 189-192

The effect of neonatal phototherapy on serum level of interlukin-6 and white blood cells' count


Pediatric Growth Disorder Research Center, 17th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Correspondence Address:
Dr. Marjaneh Zarkesh
Pediatric Growth Disorder Research Center, 17th Shahrivar Hospital, Namjoo St., Rasht
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2249-4847.191260

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Introduction: Recent progress in medical sciences approved phototherapy (PT) as a standard method of treatment and care for hyperbilirubinemia in the neonatal period. Previous studies which assessed the effect of PT on serum cytokines levels and white blood cells' (WBCs) count in infants mentioned different results. The aim of this study was to investigate the effect of neonatal PT on serum level of interleukin-6 (IL) and WBCs' count in healthy neonates with hyperbilirubinemia. Materials and Methods: This is a cross-sectional analytic study, which was conducted on 97 term newborns admitted to 17 th Shahrivar Hospital, Rasht (Northern part of Iran), with the chief complaint of indirect hyperbilirubinemia. Data were gathered by a form, which consisted of demographic characteristics and laboratory results. Four lamps with a wavelength of 400-500 nm were used at a distance of 30 cm for PT. Blood samples were taken to measure WBCs' count and IL-6 level before and 48 h after PT. Data were analyzed by t-test and Pearson's correlation coefficient in SPSS 19 software. Results: The mean age of the infants was 6.82 ± 2.16 days and 62.9% were males. The mean amount of WBCs before and after PT was 9235 ± 2215 and 9700 ± 2163, respectively (P = 0.001). The mean level of IL-6 before and after PT was 1.14 ± 0.98 and 1.42 ± 1.17, respectively (P = 0.004). There was a positive correlation between WBCs' count and IL-6 levels before and after PT (P < 0.001). Conclusions: Our findings demonstrated that an increased level of serum IL-6 and WBCs' count in healthy term neonates after PT could be indicated as its complications. Therefore, it seems that PT can change the function of the neonatal immune system.


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